What We Do?
We investigate molecular mechanisms by which RNA-binding proteins promote specialized functions in healthy and diseased cells.
Why genetic mutations cause disease?
Most disease-causing mutations in humans are not in sequences that code for proteins, but rather in sequences that regulate gene expression. These regulatory sequences are recognized by more than 1000 RNA-binding proteins which bind sequences in RNA and/or structures that RNA molecules can adopt.
It is therefore not surprising that defects in RNA-binding proteins function underlie many human diseases, including certain neurological diseases, muscular atrophies, metabolic disorders and cancer. Thus, the main objective of our research is to provide a better understanding into the functions of RNA-binding proteins and how they become defective in certain pathologies. This knowledge can provide new avenues for the development of therapies based on RNA-binding proteins or RNA.
January 9 was François’ birthday. We don’t really know how old he is…that remains to be solved! We had an...
We are welcoming two rotations students for the winter 2021 term: Ève Dandonneau (Pharmacology) and Cédric Boulanger (Biochemistry). Ève and...
Congratulations Lauren! Lauren Kwiatek won the 1st prize of a photo competition for international students of the Université de Sherbrooke entitled “My...
Congratulation to Anne-Marie for her second 1st author paper accepted for publication in Nucleic Acids Research.
Characterization of a novel function for PABPN1: the product of the oculopharyngeal muscular dystrophy disease gene
Congratulations to Yann and Carlo for driving this great work.
Congratulations to Yann Vanrobeays
We are located at the Pavillon de Recherche Appliquée sur le Cancer and are affiliated with the Department of Biochemistry and Functional Genomics of the Université de Sherbrooke.
Our work is funded by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), and the Canada Foundation for Innovation (CFI). We are part of the Sherbrooke Riboclub. We invite you to explore our site to discover who we are, what interests us, and our latest achievements.